Integrated Microfluidic Protein Analysis System
LSU Reference: 0622
Inventors:
- Steven A. Soper
- Guofang Chen
- Robin L. McCarley
- Hamed Shadpour
Status:
- Under Patent Prosecution
Description: Integrated electrophoresis, solid-phase microreactors and electrochromatographic units have been placed on an inexpensive, mass-producible polymeric “chip”
Applications:
- Rapid protein analysis
- Biomarker discovery
- Drug discovery
- Plasma protein diagnostics
- Bioterrorism defense
- Forensics
Advantages:
- Small sample size
- Unprecedented resolving power and accuracy
- Superior speed
- Mobile and remote capability
Abstract: A fully-integrated, automated microfluidic sample processing system for complete proteomic analysis requires extremely small sample volumes and utilizes built-in conductivity sensors that eliminate the need for cumbersome, labor-intensive and potentially artifact-producing protein labeling. Novel “nanopost” technology that exposes the sample stream to unprecedented surface area is used in the digestion microreactor module; these nanoposts are easily modified through adfixing and immobilizing catalysts such as proteolytic enzymes, if desired.
This page was last updated Friday, November 19, 2010
